Differential Gene Expression Analysis of Placentas with Increased Vascular Resistance and Pre-Eclampsia Using Whole-Genome Microarrays

Table 4

Results from the KEGG signaling pathway analyses and the InterPro protein domain analyses.

KEGG pathway analyses	KEGG ID	𝑃-value	FC
Pathway
PE compared to controls
Neurodegenerative disorders	HSA01510	.04	9.1
SOD1 and PSEN1
PE without notch compared to notch
Antigen processing and presentation	HSA04612	.04	3.1
HLA-B, HSP90AA1, PSME2, and CD74
PE with notch compared to notch
Ubiquitin mediated proteolysis	HSA04120	.02	12.0
UBE2E2, TCEB2, and ANAPC2
Notch compared to controls
Leukocyte transendothelial migration	HSA04670	.03	5.7
ACTG1, FKSG30, CXCR4, and CLDN5
Focal adhesion	HSA04510	.03	4.0
ACTG1, FKSG30, FLT1, and CAV1
InterPro protein domain analyses	InterPro ID	𝑃-value	FC
InterPro term
PE compared to controls
HEAT	IPR000357	.05	4.5
TNPO1 and PPP2R1A
Ras small GTPase, Rab type	IPR003579	.05	3.6
RAB9B, RAB17, and RHOH
PE compared to notch
HEAT	IPR000357	.003	4.3
ARMC8, IPO13, PPP1R12B, and GCN1L1
H+ transporting ATPase, proton pump	IPR000695	.008	21.4
ATP13A1 and ATP2A2
Haloacid dehalogenase-like hydrolase	IPR005834	.01	5.7
ATP13A2, ATP13A1, and ATP2A2
PE with notch compared to notch
ATPase, F0/V0 complex	IPR002379	.02	7.4
ATP6V0C and ATP5G1
Notch compared to controls
Actin	IPR004001	.04	44.1
ACTG1 and FKSG30

PE: pre-eclampsia, FC: fold change.