Maternal Thyroid Dysfunction and Risk of Seizure in the Child: A Danish Nationwide Cohort Study
Figure 3
Cumulative percentages of children with no diagnosis of seizure (neonatal seizure, febrile seizure, or epilepsy) by follow-up time from birth of the child and maternal diagnosis of thyroid dysfunction (none, hyperthyroidism, hypothyroidism). Cox regression model. Outcome: a diagnosis of seizure (neonatal seizure, febrile seizure, or epilepsy). Exposure: maternal diagnosis of hyperthyroidism, hypothyroidism, or no maternal thyroid dysfunction. Diagnoses were registered in the Danish National Hospital Register before January 1, 2007. Model included gender of the child (boy/girl), birth year (<1980, 1980–1982, 1983–1985, 1986–1988, 1989–1991, 1992–1994, 1995–1997, 1998–2000, 2001–2003, 2004–2006), and the following maternal variables obtained at the time of the child’s birth: age (<20, 20–24, 25–29, 30–34, 35–39, ≥40 years), parity including index pregnancy (1, 2, 3, ≥4), cohabitation (married/not married), income (1st, 2nd, 3rd, 4th quartile), origin (born in Denmark/not born in Denmark), residence (East/West Denmark), and maternal diagnosis of febrile seizure and/or epilepsy registered in the Danish National Hospital Register (DNHR) before January 1, 2007 (yes/no). 317 cases were censored (febrile seizure , epilepsy , and epilepsy and febrile seizure ), all because of emigration. Distribution of the censored cases by exposure group: no hyper- or hypothyroidism (), hyperthyroidism (), and hypothyroidism ().
