OmpA-Like Proteins of Porphyromonas gingivalis Mediate Resistance to the Antimicrobial Peptide LL-37

Figure 2

Sensitivity of the single OmpALP-deficient strains of P. gingivalis to the bactericidal activities of hBD1 and LL-37. (a, b) Approximately 10⁷ wild-type, Pgm6-deficient, Pgm7-deficient, or Pgm6/Pgm7-deficient bacterial cells were suspended in sTSB containing hBD1 or LL-37 (5 μM) and anaerobically cultured for 6 and 24 h. Bacterial survival was assessed by ATP production. Data are expressed as mean ± SD (n= 3). p < 0.05, one-way ANOVA and Dunnett’s test for post hoc comparisons (μc≠μi).

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