SARS-CoV-2, Early Entry Events

Figure 1

Schematic of the CoV S protein primary structure and cleavage sites. Arrows indicate cleavage sites (S₁/S₂) resulting in S₁ and S₂ subunits with a cleavage site () located in the S₂ subunit. FP = fusion peptide; HR1 and HR2 = heptad repeat regions 1 and 2; TM = transmembrane anchor; CP = cytoplasmic domain; NTD = N-terminal domain; RBD = receptor-binding domain; RBM = receptor-binding motif; SP = signal peptide. Taken from Depfenhart, M., de Villiers, D., Lemperle, G., et al., Inter. Emerg. Med., vol. 15, pp. 801–812, 2020.