The Pattern of Microorganisms and Drug Susceptibility in Pediatric Oncologic Patients with Febrile Neutropenia

Table 7

Therapeutic response in febrile neutropenic children with Gram-negative bacterial infection.

Characteristics	Non-antibiotics-resistant bacterial infection (N = 84)	Antibiotics-resistant bacterial infection (N = 20)	value^+
Fever days after empirical antibiotic therapy (median, range)	7 (1, 36)	15 (8, 23)	0.001
Clinical outcome	24 (28.6%)	10 (50%)	0.109
Oxygen therapy	22 (26.2%)	9 (45%)	0.11
Shock	21 (25%)	8 (40%)	0.266
Admission to the intensive care unit	12 (14.3%)	7 (35%)	0.05
Renal dysfunction	3 (3.6%)	4 (20%)	0.024
Hepatic dysfunction	8 (9.5%)	1 (5%)	0.477
Mechanical ventilator care	2 (2.4%)	5 (25%)	0.124
Duration of hospitalization (median, range)	29 (1, 150)	31 (7, 43)	0.790
Overall 2-week mortality	3 (3.6%)	4 (20%)	0.024

value calculated by the Mann–Whitney test or Fisher’s exact test as appropriate.