Trypanosoma congolense Infections: Induced Nitric Oxide Inhibits Parasite Growth In Vivo
Figure 6
CD11b−/− mice infected with T. congolense have a higher production of nitric oxide and show better control of the initial parasitemia than infected wild-type mice. Mice were infected with 103T. congolense TC13. The first parasitemia was shown to be significantly lower in infected CD11b−/− mice than in infected wild-type (WT) mice (a). Spleen cell cultures (day 6) of infected CD11b−/− mice produced significantly more nitrite than spleen cell cultures of infected WT mice (b). Cytokines in the supernatants of spleen cell cultures of CD11b−/− mice and wild-type mice 6 days after infection with T. congolense (c–f). Note: Infected CD11b−/− mice had a significant decrease in production of MCP-1 (d) but no detectable differences in production of TNF-α (c), IL-10 (f), or IFN-γ (e). *, **.
