Pomegranate (Punica granatum) Peel Inhibits the In Vitro and In Vivo Growth of Piroplasm Parasites

Table 1

IC₅₀ values of pomegranate (Punica granatum) peel, diminazene aceturate, and other previously used herbal antibabesial drugs evaluated for bovine Babesia and equine Babesia and Theileria parasites.

Organism	IC50 (μg/ml)^a
	Punica granatum	Diminazene aceturate	Zingiber officinale rhizome^b	Turmeric (Curcuma longa)^c
B. bovis
B. bigemina				ND
B. divergens			ND
T. equi
B. caballi

^aIC₅₀ values for pomegranate (Punica granatum) peel and diminazene aceturate were calculated on the fourth day based on the growth inhibitions determined using fluorescence-based assay in three separate experiments. Each drug concentration was made in triplicate in each experiment, and the final obtained IC₅₀ represents the mean and standard deviation of three separate experiments. ND: not detected. ^bThe IC₅₀ was reported in the previous study [10]. ^cThe IC₅₀ was reported in the previous study [17].