Finding Transcription Factor Binding Motifs for Coregulated Genes by Combining Sequence Overrepresentation with Cross-Species Conservation

<table><i>Z</i>-value of the motifs. We choose the 100 sequences found in the upstream of <i>Ace2</i>-regulated <i>S. cerevisiae</i> genes with the smallest overrepresentation <i>P</i>-values and compute their <i>Z</i>-values in the multiple alignments of orthologous upstream sequences of the four related yeast species.  The arrow points to the known motif <i>GCTGGT</i> of Ace2 in <i>S. cerevisiae</i>. The <i>Z</i>-value of the known binding motif is greater than that of the most other sequences. </table>

Journal of Probability and Statistics

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Figure 3

Figure 3: Finding Transcription Factor Binding Motifs for Coregulated Genes by Combining Sequence Overrepresentation with Cross-Species Conservation 