Research Article
Parameter Estimation of Population Pharmacokinetic Models with Stochastic Differential Equations: Implementation of an Estimation Algorithm
Table 1
Mean estimates and 95% credibility interval in brackets obtained from the SDE mixed-effects models and ODE models on 500 simulated datasets.
| Parameter | True value | SDE estimation (confidence interval) | ODE estimation (confidence interval) |
| | 0.2 | 0.1999 (0.1999, 0.2006) | 0.0984 (−0.6448, 0.8416) | | 0.5 | 0.4755 (0.47503, 0.5213) | 0.5339 (0.4089, 0.6589) | | 0.25 | 0.2501 (0.2499, 0.2501) | 0.1815 (−0.0303, 0.3932) | | 0.01 | 0.0173 (0.0063, 0.0467) | — | | 0.1 | 0.1482 (0.0176, 0.1812) | — | | 0.02 | 0.0174 (0.0035, 0.0402) | — | | 0.2 | 0.1488 (0.1343, 0.2441) | — | | 0.1 | 0.0793 (0.0402, 0.1091) | — | | 0.1 | 0.1087 (0.0767, 0.1515) | — |
|
|