Human Ace D/I Polymorphism Could Affect the Clinicobiological Course of COVID-19

Table 4

Comparison of the clinical and laboratory characteristics of the COVID-19 patients at admission according to alleles.

	Alleles
	DD	DI	II
Pneumonia(%)				0.021
Severe	2 (8)	10 (31.3)	—
Nonsevere	23 (92)	22 (68.7)	8 (100)
Need for oxygen (%)	3 (6.7)	12 (20.3)	—	0.06
Presence of fever (%)	23 (51.1)	27 (45.8)	3 (37.5)	0.73
Median body temperature (°C)	38 [36.5-39.7]	37.7 [36.4-39.9]	37.8 [36.6-39.1]	0.92
Ferritin (μg/L)	54.2 [5.3-3704]	49.9 [2.7-1300]	64.5 [9.1-273]	0.93
D-dimer (mg/L) [median]	0.36 [0.2-2.8]	0.38 [0.2-1.9]	0.36 [0.2-0.7]	0.91
CRP (mg/dL)	0.76 [0.1-24.6]	0.81 [0.1-14]	0.76 [0.12-1.35]	0.97
NLR	2.6 [0.89-14.5]	2.7 [0.66-14.1]	1.9 [0.83-4.34]	0.47
LDH (U/L)	165 [120-477]	183 [122-449]	188 [110-272]	0.59
CK (U/L)	76.5 [9-311]	83 [16-1648]	69.5 [35-150]	0.34
AST (U/L)	22.5 [15-98]	25 [12-81]	29 [17-56]	0.51
Total bilirubin (mg/dL)	0.45 [0.24-0.98]	0.42 [0.1-1.39]	0.44 [0.15-0.90]	0.76
BUN (mg/dL)	13.3 [5.7-43.5]	12.2 [4.1-28.3]	8.84 [7-18.1]	0.1
Creatinine (mg/dL)	0.7 [0.49-3.65]	0.79 [0.44-1.2]	0.67 [0.55-0.96]	0.4
ESR (mm/h)	13 [2-62]	12 [2.7-56]	15 [2-27]	0.89

AST: aspartate aminotransferase; BUN: blood urea nitrogen; CK: creatinine kinase; CRP: C-reactive protein; ESR: erytrocyte sedimentation rate; LDH: lactate dehydrogenase; NLR: neutrophile to lymphocyte ratio. μg/L: micrograms per liter; mg/L: milligrams per liter; U/L: units per liter; mg/dL: milligrams per decilitre; mm/h: millimeters per hour. Brackets indicate minimum and maximum ranges. Parentheses indicate percent value.