Angiotensin Receptor Blocker and Neprilysin Inhibitor Suppresses Cardiac Dysfunction by Accelerating Myocardial Angiogenesis in Apolipoprotein E-Knockout Mice Fed a High-Fat Diet

Figure 1

Changes in body weight and blood pressure. Changes in (a) body weight and (b) blood pressure, including systolic blood pressure and diastolic blood pressure in each group. CTL: control group; VAL: valsartan group; SAC: sacubitril group; VAL/SAC: valsartan plus sacubitril group. The round marker and solid line, square marker and dotted line, triangle marker and dashed line, and rhombus marker and chain line indicate CTL, VAL, SAC, and VAL/SAC. CTL (), VAL (), SAC (), and VAL/SAC () were investigated. and ‡ indicate significant differences compared with CTL and SAC during the same week, respectively.

(a)

(b)