Angiotensin Receptor Blocker and Neprilysin Inhibitor Suppresses Cardiac Dysfunction by Accelerating Myocardial Angiogenesis in Apolipoprotein E-Knockout Mice Fed a High-Fat Diet

Figure 5

Regulation of NF-κB and activity of mitochondria and lysosome. mRNA expression levels of (a) Nfkbia, (b) Ikbkb, (c) Ikbkg, (d) Lamp2, and (e) Pink1 in each group. NF-κB: nuclear factor-kappa B; Nfkbia: NF-κB inhibitor alpha; Ikbkb: an inhibitor of NF-κB kinase subunit beta; Ikbkg: an inhibitor of NF-κB kinase regulatory subunit gamma; Lamp2: lysosome-associated membrane glycoprotein 2; Pink1: phosphatase and tensin homolog deleted on chromosome 10-induced kinase 1; CTL: control group; VAL: valsartan group; SAC: sacubitril group; VAL/SAC: valsartan plus sacubitril group. CTL (), VAL (), SAC (), and VAL/SAC () were investigated. , †, and ‡ indicate significant differences compared with CTL, VAL, and SAC, respectively.

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