Berberine Reshapes the Balance of the Local Renin-Angiotensin System by Modulating Autophagy under Metabolic Stress in Pancreatic Islets

Figure 1

Palmitate triggered an imbalance in the RAS in a concentration-dependent manner. After islet cells were incubated with palmitate for the indicated durations, ACE (a), ATR1 (b), ACE2 (c), Mas (d), and ACE/ACE2 (e) mRNA expression was determined by QPCR. (f) The ACE and ACE2 protein expression was determined by immunoblotting. Data are shown as the of three independent experiments. ; ;.

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