Alterations in Gene Expression of Renin-Angiotensin System Components and Related Proteins in Colorectal Cancer

Table 3

Use of RAS inhibitors and other medications in various cancers.

Medication	Cancer type	Effect of medication on cancer type	Citation
inhibitors	CRC	Downregulated tumor growth	Makar et al. [17]
years	CRC	Decreased RISK of CRC	Makar et al. [17]
CCB years	CRC	No change	Makar et al. [17]
Statins, ACEI, CCBs, diuretics	CRC	No change in risk of CRC	Boudreau et al. [100]
ACEI (dose related)	Adenomatous polyps	Decreased risk of CRC via downregulation of adenomatous polyps	Kedika et al. [18]
ACEI and ARB combination	Cancer (nonspecific)	Increased risk of cancer	Bangalore et al. [101]
ACEI	Breast, prostate, renal, and small cell cancer	Improved survival outcomes	Coulson et al. [86]
Losartan (ARB)	Breast Cancer	Delays occurrence and progression of invasive breast cancer	Coulson et al. [86]
Captopril (ACEI)	CRC liver metastases	Decreased tumor metastases	Neo et al. [15]