IgA Nephropathy with Macroproteinuria and a GFR of 20-30 ml/min/1.73 m² May Still Benefit from RAS Inhibition

Table 2

Univariate and multivariate Cox regression analysis of IgAN patients with stage 4 CKD.

Variables	Univariate analysis		Multivariate analysis
	HR (95% CI)		HR (95% CI)
Age (y)	0.962 (0.925-1.001)	0.055
Gender	1.496 (0.619-3.615)	0.371
SBP	0.998 (0.969-1.029)	0.912
DBP	1.023 (0.976-1.073)	0.343
MAP	1.018 (0.989-1.046)	0.223
Hb	0.977 (0.949-1.006)	0.122
eGFR	0.801 (0.696-0.921)	0.002	0.829 (0.724-0.950)	0.007
UA	0.998 (0.992-1.004)	0.554
iPTH	1.001 (0.999-1.002)	0.526
TC	1.178 (0.902-1.539)	0.230
TG	1.089 (0.771-1.537)	0.629
URBC	0.999 (0.994-1.003)	0.569
24 h-UP	1.157 (0.962-1.391)	0.121	1.108 (0.922-1.331)	0.275
Hypertension	1.017 (0.421-2.460)	0.970
RASi	0.259 (0.103-0.653)	0.004	0.356 (0.133-0.953)	0.040
IS	0.608 (0.252-1.466)	0.268

SBP, systolic blood pressure; DBP, diastolic blood pressure; MAP, mean arterial pressure; RASi, renin-angiotensin system inhibitor; IS, immunosuppressive agents; Hb, hemoglobin; eGFR, estimated glomerular filtration rate; UA, uric acid; PTH, parathyroid hormone; TC, total cholesterol; TG, triglyceride; 24 h-UP, 24 h urinary protein excretion; URBC, urinary red blood cells.