New Viral Diseases and New Possible Remedies by Means of the Pharmacology of the Renin-Angiotensin System

Figure 4

Schematic depiction of intracellular NRLP3 inflammasome activation due to SARS-CoV-2 and Ang II excess, and its consequences. Internalized ACE2 bound to virions undergoes proteasomal degradation. Intracellular SARS-CoV-2 N protein leads to direct NRLP3 inflammasome activation.