New Viral Diseases and New Possible Remedies by Means of the Pharmacology of the Renin-Angiotensin System

Table 1

Opposing effects of Ang II and Ang1-7.

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Ang II leads to:

NADPH-oxidase-mediated reactive oxygen species production

Increased collagenolytic activity of MMP-9

Reduced ACE2 cell expression

Induction of the enzymatic activity of ADAM-17, leading to increased circulating levels of TNF-α

NLRP3 inflammasome activation

High transcription of NF-κB leading to production of proinflammatory cytokines

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Ang1-7 leads to:

Increased plasma levels of superoxide dismutase 2 and reduced oxidative stress

Reduced ACE function

Increased production of the vasodilator NO, prostaglandins H2 and G2, and prostacyclin

Inhibition of NADPH-oxidase-mediated reactive oxygen species production

Inhibition of NLRP3 inflammasome activation

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