Review Article
New Viral Diseases and New Possible Remedies by Means of the Pharmacology of the Renin-Angiotensin System
Table 1
Opposing effects of Ang II and Ang1-7.
| Ang II leads to: | NADPH-oxidase-mediated reactive oxygen species production | Increased collagenolytic activity of MMP-9 | Reduced ACE2 cell expression | Induction of the enzymatic activity of ADAM-17, leading to increased circulating levels of TNF-α | NLRP3 inflammasome activation | High transcription of NF-κB leading to production of proinflammatory cytokines |
| Ang1-7 leads to: | Increased plasma levels of superoxide dismutase 2 and reduced oxidative stress | Reduced ACE function | Increased production of the vasodilator NO, prostaglandins H2 and G2, and prostacyclin | Inhibition of NADPH-oxidase-mediated reactive oxygen species production | Inhibition of NLRP3 inflammasome activation |
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