Polymorphisms in the Renin-Angiotensin System and eNOS Glu298Asp Genes Are Associated with Increased Risk for Essential Hypertension in a Mexican Population
Table 2
eNOS Glu298Asp genotype and allele frequency in patients with essential hypertension and controls.
Patients ()
Controls ()
value
OR (95% CI)
Genotype
Glu/Glu,
114 (50.8)
146 (70.2)
0.001
OR 2.04 (1.36–3.15)
Glu/Asp,
96 (42.9)
58 (27.9)
Asp/Asp,
14 (6.3)
4 (1.9)
Dominant model
Asp/Asp vs. Glu/Asp+Glu/Glu,
14 vs.
vs. 146
0.02
(1.02–12.45)
Recessive model
Glu/Glu vs. Glu/Asp+Asp/Asp,
114 vs.
146 vs.
0.001
(1.50–3.44)
Allele frequency
Glu,
324 (84.5)
350 (81.7)
0.001
(1.43–2.88)
Asp,
124 (15.5)
66 (18.3)
Data presented are number and % of patients. CI: confidence interval; odds ratio, .
