Biochemical Evaluation by Confirmatory Tests after Unilateral Adrenalectomy for Primary Aldosteronism

Table 2

Definition of the biochemical outcome by confirmatory tests in PASO criteria.

ARR (>20) basal PAC	Complete
	Partial	and decrease
	Absent	and decrease
CCT	Complete	decrease
	Partial	ND
	Absent	decrease
SIT	Complete	ng/dL
	Partial	PAC 5.0-10.0 ng/dL
	Absent	ng/dL
FUT	Complete	ng/mL/h
	Partial	ND
	Absent	ng/mL/h
U-Aldo	Complete	<10 μg/day
	Partial	10~12 μg/day
	Absent	>2 μg/day

Criteria shown by Ref. [8] are adopted in this study. PASO: primary aldosteronism surgical outcome; ARR: aldosterone-renin ratio; PAC: plasma aldosterone concentration; CCT: captopril challenge test; SIT: saline infusion test; FUT: furosemide upright test; U-Aldo: 24 h urine aldosterone; ND: not defined. FUT is not included in the PASO criteria; therefore, the diagnostic criteria of the Japan Endocrine Society are adopted. U-Aldo is determined according to the criteria for the oral salt loading test in the PASO criteria. BP, estimated glomerular filtration rate (eGFR), basal PRA, and basal PAC levels were measured before and after Adx. Data are presented as the deviation. The statistical significance of the differences in clinical data values was assessed using the Wilcoxon signed-rank test or Fisher’s exact test. Statistical significance was set at . JMP Pro version 16.2.0 (SAS Institute Japan Ltd., Tokyo, Japan) was used for the statistical analysis.