Timing Matters: Effects of Early and Late Estrogen Replacement Therapy on Glucose Metabolism and Vascular Reactivity in Ovariectomized Aged Wistar Rats

Figure 4

Vascular response to KCl and acetylcholine increases at 10-week postovariectomy. (a) In vitro vascular response to KCl in aortic rings. 10 w and 10 w-early E2 increase aortic contraction vs. the Sham group ( and , respectively). (b) In vitro vascular response to Ach in aortic rings. 10 w and 10 w-early E2 showed an increase in vascular relaxation response to Ach vs. the sham group ( and , respectively). KCl: potassium chloride; Ach: acetylcholine. Values are the . Two-way ANOVA and Sidak’s post hoc test were used to assess differences in the data.

(a)

(b)