Timing Matters: Effects of Early and Late Estrogen Replacement Therapy on Glucose Metabolism and Vascular Reactivity in Ovariectomized Aged Wistar Rats

Table 1

EC50 (M) and PD2 (-log M) values to KCl, ACh, and Ang II.

Group	KCL		ACh		Ang II
	EC50 (M)	PD2	EC50 (M)	PD2	EC50 (M)	PD2
Sham		1.58		9.36		7.37
10 w		1.35		5.70		7.17
20 w		1.55		8.36		6.89
10 w-early E2		1.26		3.47		7.27
20 w-late E2		1.78		8.75		7.11

Effective concentration 50 (M). PD2: -log M. These results are the mean of 10 experiments. One-way ANOVA followed by a Student-Newman Keuls post hoc test. vs. sham.