Timing Matters: Effects of Early and Late Estrogen Replacement Therapy on Glucose Metabolism and Vascular Reactivity in Ovariectomized Aged Wistar Rats

Table 2

Blood pressure and heart rate changes depend on postovariectomy time.

Parameter	Sham	10 w	10 w-early E2	20 w	20 w-late E2
SBP (mmHg)
DBP (mmHg)
MBP (mmHg)
HR (beats/min)

DBP increases at 20 w postovariectomy with and without ERT vs. sham (). MBP: mean blood pressure; SBP: systolic blood pressure; DBP: diastolic blood pressure; HR: heart rate. The results are the (). One-way analysis of variance (ANOVA) followed by the Student-Newman-Keuls post hoc test was used for comparisons between groups.