Review on the Biogenesis of Platelets in Lungs and Its Alterations in SARS-CoV-2 Infection Patients

Table 1

The table representing the pathogenesis of viral infections involving lung and platelets.

Viral strains	Pathogenesis involving lung and thrombocytopenia	References
Influenza virus (H1N1)	(i) Binds to alpha glucans on the platelet surface and affects the platelet homeostasis; (ii) The interaction of sialic acid between the platelets and the lungs, mediates the clearance of platelets	[56]
Measles virus	(i) The virus upon infection causes thrombocytopenia as it causes damage to the lungs during the time of infection	[57]; [58]
Fetal parvovirus B19	(i) The thrombocytopenia is induced during the time of infection due to the external stimulus of the virus on erythroid progenitor cells and megakaryocytes	[60]; [61]
SARS-CoV-2	(i) The plasma level of thrombopoietin (TPO) increases which in turn decreases the expression of the TPO-receptor by means of the C-mpl gene that ends up causing thrombocytopenia	[63]