Renin Trajectories and Outcome in Stable Heart Failure with Reduced Ejection Fraction (HFrEF) on Contemporary Therapy: A Monocentric Study from an Austrian Tertiary Hospital Outpatient Clinic
Table 2
Crude and multivariable Cox regression analysis assessing the impact of baseline and 1-year delta renin levels on all-cause mortality and unplanned HF hospitalization.
Crude HR (95% CI)
value
Model I HR (95% CI)
value
Model II HR (95% CI)
value
Model III HR (95% CI)
value
All-cause mortality
Baseline renin (per 100 μIU/ml increase)
1.01 (0.99-1.02)
0.414
1.01 (1.00-1.03)
0.062
1.02 (1.00-1.03)
0.037
1.01 (0.99-1.02)
0.313
Δ-Renin % at 1 year (per 10% increase)
1.00 (1.00-1.00)
0.241
1.00 (1.00-1.00)
0.341
1.00 (1.00-1.00)
0.350
1.00 (1.00-1.00)
0.219
Unplanned HF hospitalization
Baseline renin (per 100 μIU/ml increase)
1.01 (1.00-1.02)
0.015
1.01 (1.00-1.02)
0.019
1.01 (1.00-1.02)
0.014
1.01 (1.00-1.02)
0.066
Δ-Renin % at 1 year (per 10% increase)
1.00 (1.00-1.00)
0.987
1.00 (1.00-1.00)
0.999
1.00 (1.00-1.00)
0.861
1.00 (1.00-1.00)
0.703
Model I: adjusted for age, sex, and body mass index. Model II: model I + additional adjustment for comorbidity type 2 diabetes, coronary artery disease, and hypertension. Model III: adjusted for NT-proBNP, NYHA class, and aldosterone.