Research Article
Genetic Variants Associated with High Susceptibility of Premature Ischemic Stroke
Table 5
Genotype distribution and allele frequencies of polymorphisms associated with ischemic stroke in young Mexican population.
| | Gene | Genotype frequencies | value | Allele frequencies | value | | Case | Control | Case | Control |
| | AGT | M235T | | M235T | | | T/T | C/T | C/C | T/T | C/T | C/C | | T | C | T | C | | | 148 (59.2) | 74 (29.6) | 28 (11.2) | 170 (68.0) | 68 (27.2) | 12 (4.8) | 0.001 | 370 (74.0) | 130 (26.0) | 408 (81.6) | 92 (18.4) | 0.003 | | T174M | | T174M | | | C/C | C/T | T/T | C/C | C/T | T/T | | C | T | C | T | | | 186 (74.4) | 60 (24.0) | 4 (1.6) | 208 (83.2) | 41 (16.4) | 1 (0.4) | 0.01 | 432 (86.4) | 68 (13.6) | 457 (91.4) | 43 (8.6) | 0.001 | | ACE | I/D | | I/D | | | I/I | I/D | D/D | I/I | I/D | D/D | | I | D | I | D | | | 88 (35.2) | 118 (47.2) | 44 (17.6) | 98 (39.2) | 116 (46.4) | 36 (14.4) | 0.25 | 294 (59.0) | 206 (41) | 312 (62.4) | 188 (37.6) | 0.24 | | F2 | G20210A | | G20210A | | | G/G | G/A | A/A | G/G | G/A | A/A | | G | A | G | A | | | 250 (100) | 0 (0) | 0 (0) | 250 (100) | 0 (0) | 0 (0) | NS | 250 (100) | 0 (0) | 250 (100) | 0 (0) | NS | | F5 | G1691A | | G1691A | | | G/G | G/A | A/A | G/G | G/A | A/A | | G | A | G | A | | | 250 (100) | 0 (0) | 0 (0) | 250 (100) | 0 (0) | 0 (0) | NS | 250 (100) | 0 (0) | 250 (100) | 0 (0) | NS | | F7 | G10976A | | G10976A | | | G/G | G/A | A/A | G/G | G/A | A/A | | G | A | G | A | | | 204 (81.6) | 45 (18.0) | 1 (0.4) | 206 (82.4) | 40 (16.0) | 4 (1.6) | 0.91 | 453 (90.6) | 47 (9.4) | 452 (90.4) | 48 (9.6) | 0.91 | | AGTR1 | A1166C | | A1166C | | | A/A | A/C | C/C | A/A | A/C | C/C | | A | C | A | C | | | 164 (65.6) | 68 (27.2) | 18 (7.2) | 192 (76.8) | 52 (20.8) | 6 (2.4) | 0.01 | 396 (79.2) | 104 (20.8) | 436 (87.2) | 64 (12.8) | 0.001 | | TSP | N700S | | N700S | | | N/N | N/S | S/S | N/N | N/S | S/S | | N | S | N | S | | | 228 (91.2) | 22 (8.8) | 0 (0.0) | 226 (90.4) | 24 (9.6) | 0 (0.0) | 0.96 | 478 (95.2) | 22 (8.8) | 476 (95.2) | 24 (4.8) | 0.76 |
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MTHFR: methylenetetrahydrofolate reductase; eNOS: endothelial nitric oxide synthase; AGT: angiotensinogen; ACE: angiotensin-converting enzyme; F2: gene of coagulation factor II; F5: gene of coagulation factor V or Leiden; F7: gene of coagulation factor VII; PAI-1gene of the plasminogen activator inhibitor type 1; CPB2: gene of thrombin activatable fibrinolysis inhibitor; OR: odds ratios; CI: confidence interval.
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