Review Article

Design and Development of Biosensors for Progesterone Detection

Table 2

Performance comparison of progesterone biosensor with composite material.

Type of biosensorFunctional materialSamplesLinear rage (μmol/L)LOD (nM)References

Electrochemical biosensors based on carbonaceous nanomaterials and metal nanomaterials
 Electrochemical biosensors based on aptamerGQDs-NiO-AuNFs/f-MWCNTsHuman serum samples and drug formulations0.00001-10.00186[39]
Au-CuO-Cu2OHuman serum0.0005-0.1800.17[27]
 Electrochemical biosensors based on nonenzymaticWO3NBs@GRBlood0.025-1792.54.28[26]

Electrochemical sensor based on carbonaceous nanomaterial and polymer modification
 Electrochemical sensorGQDs-PSSAHuman serum0.001-6.00.31[41]

Electrochemical sensors based on composite modification of biomaterials with carbon nanomaterials, metal nanomaterials, or polymers
 Electrochemical biosensors based on immuneThi-GOMilk0.00006369-0.06369[28]
 Electrochemical biosensors based on nonenzymaticGO-IMZDrug samples0.22-14.064[30]
 Electrochemical biosensors based on enzymeCYP3A4/PNGFsLaboratory control standard[31]
 Surface plasmon resonance imaging optical biosensorThionine-graphene oxide (Thi-GO) and biotin-avidin system (BAS)[52]

Optical biosensor based on composite material modification
 Light-emitting resonance energy transfer (LRET) optical signal sensorNaYF4@NaYF4:Yb, tm@NaYF4Human serum0.004331[44]
 Optical biosensor (quantum dot Forster resonance energy transfer (FRET) method)QD-TF-FRETArtificial urine[45]
 Fluorescent biosensorPhotonic crystal (PC) and UCNPsSerum[43]

Others
 Electrochemical biosensors based on nonimmuneGCE/AuNPsMilk35-80011.4[37]
 Electrochemical biosensors based on immuneMGOProgesterone standard sample0.00000001-1DPV: 0.00015; CV: 0.00017[4]

Note that LOD represents the limit of detection.