Potential Role of Meiosis Proteins in Melanoma Chromosomal Instability

Table 3

The Potential ramifications of the aberrant expression of different meiotic proteins.

Meiotic Pathway	Potential ramification in mitosis	Potential Meiotic Proteins involved
DS DNA strand breaks	Insertions, deletions, translocations	SPO11
Error prone polymerase	Point mutations	POLB
Failure of cohesin ring digestion	Tetraplody, polyploidy	REC8/SGO2
Unresolved chismata	Anaphase bridging	REC8
Failure of kinetochore separation	Chromosomal; missegregation	REC8/SGO2
Misalignment of kinetochores	Chromosomal; missegregation	REC8/monopolins