Protein Kinase Cε, Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells
Figure 3
Effects of chronic UV exposures on live epidermal stem cell population determined by flow cytometric analysis. PKCε overexpressing TG and their WT littermates were given total eight UV exposures (1.8 kJ/m2, Monday, Wednesday, and Friday). At 24 hr after the last UV exposure, mice were sacrificed and the dorsal skin removed for keratinocyte isolation. (a) Percent distribution of FACS-sorted keratinocytes following UV exposures of the indicated mice. (b) Frequency of total double positive HSCs (CD34+/α6-integrin+) keratinocytes in UV-treated mice.
