Melanoma-Targeted Chemothermotherapy and In Situ Peptide Immunotherapy through HSP Production by Using Melanogenesis Substrate, NPrCAP, and Magnetite Nanoparticles

Figure 7

NPrCAP-mediated apoptotic cell death of B16F1 melanoma cells. Assay of caspase 3/7 in cells treated with NPrCAP or TRAIL. Cells were cultured in the presence of NPrCAP, TRAIL, or propylene glycol in 96-well plates and then processed for measurement of caspases 3 and 7 using a Caspase-Glo3/7 assay kit. From Ishii-Osai et al. [46].