Cutaneous Human Papillomavirus Infection and Development of Subsequent Squamous Cell Carcinoma of the Skin
Table 5
Association of beta HPV infection in eyebrow hair and beta HPV seropositivity with the risk of subsequent SCC by index tumor HPV DNA status.
Viral infection at the time of index SCC diagnosis
HPV DNA negative index SCC
HPV DNA positive index SCC
No subsequent SCC ()
Subsequent SCC ()
HR (95% CI)
No subsequent SCC ()
Subsequent SCC ()
HR (95% CI)
HPV serology
Any beta
Beta HPV seronegative
7 (30.4)
10 (45.5)
1.00
7 (22.6)
12 (21.8)
1.00
Beta HPV seropositive
16 (69.6)
12 (54.5)
0.44 (0.18–1.03)
24 (77.4)
43 (78.9)
0.92 (0.48–1.75)
HPV infection in eyebrow hairs
Any beta
DNA negative to all beta HPV types
3 (13.6)
6 (27.3)
1.0
2 (6.7)
5 (9.4)
1.0
DNA positive to ≥1 beta HPV
19 (86.4)
16 (72.7)
0.97 (0.38–2.50)
28 (93.3)
48 (90.6)
0.30 (0.11–0.78)
Any beta 1
DNA negative
3 (25.00)
6 (33.3)
1.0
2 (11.1)
1 (2.8)
1.0
DNA positive
9 (75.0)
12 (66.7)
1.21 (0.45–3.24)
16 (88.9)
35 (97.2)
0.72 (0.09–5.45)
Any beta 2
DNA negative
3 (15.0)
6 (35.3)
1.0
1 (4.8)
5 (12.8)
1.0
DNA positive
17 (85.0)
11 (64.7)
0.85 (0.31–2.32)
20 (95.2)
34 (87.2)
0.32 (0.12–0.86)
beta HPV seropositivity was defined as seropositive to ≥1 beta HPV types versus seronegative to all beta HPV types. beta HPV infection in eyebrow hairs was defined as DNA positivity to ≥1 beta HPV types versus DNA negativity to all beta HPV types. DNA status was defined as DNA positive to one or more beta HPV types versus DNA negative to all beta HPV types. DNA status was defined as DNA positivity to species-specific beta HPV types versus DNA negative to all beta HPV types.
