The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma

Table 1

Sensitivity, specificity, positive predictive value, and negative predictive value of BerEP4 in detecting BCC with SCC as control.

Studies	BCC +	SCC + (control)
Karahan, et al. [16]	20/20	0/20
Fan, et al. [28]	51/51	-
Krahl & Sellheyer [29]	28/28	-
Ishida, et al. [30]	20/20	-
Filho, et al. [31]	20/20	-
Mashhood, et al. [32]	29/29	0/11
Tan & Sunjaya [9]	23/23	-
Kirzhner & Jakobiec [33]	13/13	-
Dasgeb, et al. [24]	24/24	1/11 (weak positive)
Patil, et al. [12]	9/9	-
Sellheyer, et al. [34]	17/17	0/75
Ansai, et al. [35]	30/31	-
BerEP4 positive	284	1
Ber EP4 negative	1	116
Total	285	117
Sensitivity	284/285 × 100 = 99.6%
Specificity	116/117 × 100 = 99.2%
Positive predictive value	284/285 × 100 = 99.6%
Negative predictive value	116/117 × 100 = 99.1%