Research Article

Comparative Analysis of Acral Melanoma in Chinese and Caucasian Patients

Table 1

Clinical and pathological parameters of AM patients in Chinese (n = 280) and Caucasians (n = 62).

ParameterChinese (n = 280) (%)Caucasian (n = 62) (%) value

Age at diagnosis (years)0.25
Median (IQR)60.5 (51–70)64.5 (49.5–75.3)

Gender0.80
Male154 (55)33 (53.2)
Female126 (46)29 (46.8)
Male to female ratio1.22 : 11.13 : 1

Pathologic stage<0.001
0/I43 (15.3)38 (61.2)
II160 (57.1)11 (17.7)
III76 (27.2)12 (19.4)
Unknown1 (0.4)1 (1.6)

Largest Diameter (cm)(0.4–10.0)(0.2–4.5)<0.001
Median (IQR)2.5 (1.7–3.5)1.0 (0.43–2.0)
Unknown90 (32.0)18 (29.0)

Location0.27
Volar192 (68.6)38 (61.3)
Foot191 (68.2)37 (59.6)
Hand1 (0.4)1 (0.7)
Subungual88 (31.4)24 (38.7)

Histology0.21
Acral lentiginous260 (92.8)60 (96.8)
Nodular8 (2.9)1 (1.6)
Superficial spreading12 (4.3)1 (1.6)

Breslow thickness (mm)0.003
Median (IQR)3.0 (1.7–5.0)1.2 (0.65–2.8)
Unknown54 (19.3)11 (17.7)

Clark Level<0.001
I10 (3.6)8 (12.9)
II/III28 (10.0)22 (35.5)
IV/V164 (58.6)18 (29.0)
Unreported/unknown78 (27.8)14 (22.6)

Ulceration<0.001
Yes185 (66.1)18 (29.0)
No87 (31.1)44 (71.0)
Unreported/unknown8 (2.8)-

SLN biopsyN/A
Yes280 (100)34 (54.8)
No28 (45.2)

SLN biopsy positive0.56
Yes85 (30.4)12 (35.3)
No195 (69.6)22 (64.7)

Number of SLN resected
Mean (SD)3.1 (2.05)2.0 (1.39)
CLND after SLNB+74/85 (87)8/12 (66.7)
Number of total LNs resected, mean (SD)8.7 (4.35)23.4 (12.1)
CLND positive27/77 (35.1)2/8 (25)0.44

SurgeryN/A
WLE173 (61.8)30 (48.4)
Amputation88 (31.4)27 (43.5)
Mohs surgery3 (4.8)
Unknown19 (6.8)2 (3.2)

Adjuvant therapyN/A
Yes238 (84.7)4 (6.5)
No32 (12.4)58 (93.5)
Unreported/unknown10 (3.9)