Research Article
Comparative Analysis of Acral Melanoma in Chinese and Caucasian Patients
Table 3
Prognostic factors associated with DSS in AM patients.
| Parameter | Univariate analysis | Multivariate analysis | Hazard ratio (95% CI) | value | Hazard ratio (95% CI) | value |
| Age (years) | | 0.08 | | | ≤60 (N = 166) | 0.68 (0.43–1.05) | | | | >60 (N = 176) | 1.0 | | | |
| Gender | | 0.001 | | 0.011 | Male (N = 187) | 2.21 (1.38–3.55) | | 1.99 (1.17–3.38) | | Female (N = 155) | 1.0 | | 1.0 | |
| Chinese vs. Caucasian | | 0.56 | | | Chinese (n = 280) | 1.26 (0.58–2.76) | | | | Caucasian (n = 62) | 1.0 | | | |
| Pathologic stage | | <0.001 | | | 0/I (n = 81) | 0.08 (0.03–0.27) | | | | II (n = 171) | 0.42 (0.27–0.66) | | | | III (n = 89) | 1.0 | | | |
| Location | | 0.69 | | | Volar (n = 230) | 0.91 (0.57–1.46) | | | | Subungual (n = 112) | 1.0 | | | |
| Breslow thickness (mm) | 1.06 (1.03–1.09) | <0.001 | 1.05 (1.01–1.09) | 0.018 |
| Clark Level (%) | | <0.001 | | | Unknown (n = 91) | 0.42 (0.23–0.77) | | | | I/II/III (n = 68) | 0.26 (0.11–0.60) | | | | IV/V (n = 183) | 1.0 | | | |
| Histology | | 0.93 | | | Nodular (n = 9) | 1.01 (0.25–4.12) | | | | Superficial spreading (n = 12) | 0.81 (0.25–2.57) | | | | Acral lentiginous (n = 321) | 1.0 | | | |
| Ulceration | | | | | Yes (n = 203) | 4.06 (2.20–6.57) | <0.001 | 3.39 (1.20–8.23) | 0.026 | No (n = 130) | 1.0 | | 1.0 | |
| SLN biopsy status | | <0.001 | | 0.003 | Positive (n = 97) | 3.45 (2.19–5.45) | | 4.10 (1.54–10.92) | | Negative (n = 217) | 1.0 | | 1.0 | |
| Surgery | | 0.88 | | | Amputation (n = 115) | 1.04 (0.64–1.68) | | | | WLE (n = 203) | 1.0 | | | |
| Adjuvant therapy | | 0.60 | | | Yes (n = 242) | 0.87 (0.51–1.47) | | | | No (n = 90) | 1.0 | | | |
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