Research Article

Comparative Analysis of Acral Melanoma in Chinese and Caucasian Patients

Table 3

Prognostic factors associated with DSS in AM patients.

ParameterUnivariate analysisMultivariate analysis
Hazard ratio (95% CI) valueHazard ratio (95% CI) value

Age (years)0.08
≤60 (N = 166)0.68 (0.43–1.05)
>60 (N = 176)1.0

Gender0.0010.011
Male (N = 187)2.21 (1.38–3.55)1.99 (1.17–3.38)
Female (N = 155)1.01.0

Chinese vs. Caucasian0.56
Chinese (n = 280)1.26 (0.58–2.76)
Caucasian (n = 62)1.0

Pathologic stage<0.001
0/I (n = 81)0.08 (0.03–0.27)
II (n = 171)0.42 (0.27–0.66)
III (n = 89)1.0

Location0.69
Volar (n = 230)0.91 (0.57–1.46)
Subungual (n = 112)1.0

Breslow thickness (mm)1.06 (1.03–1.09)<0.0011.05 (1.01–1.09)0.018

Clark Level (%)<0.001
Unknown (n = 91)0.42 (0.23–0.77)
I/II/III (n = 68)0.26 (0.11–0.60)
IV/V (n = 183)1.0

Histology0.93
Nodular (n = 9)1.01 (0.25–4.12)
Superficial spreading (n = 12)0.81 (0.25–2.57)
Acral lentiginous (n = 321)1.0

Ulceration
Yes (n = 203)4.06 (2.20–6.57)<0.0013.39 (1.20–8.23)0.026
No (n = 130)1.01.0

SLN biopsy status<0.0010.003
Positive (n = 97)3.45 (2.19–5.45)4.10 (1.54–10.92)
Negative (n = 217)1.01.0

Surgery0.88
Amputation (n = 115)1.04 (0.64–1.68)
WLE (n = 203)1.0

Adjuvant therapy0.60
Yes (n = 242)0.87 (0.51–1.47)
No (n = 90)1.0