MDM4 Isoform Expression in Melanoma Supports an Oncogenic Role for MDM4-A

Figure 6

MDM4-A isoform correlates with poor survival. The subjects with an exon 9 percent spliced in (PSI) greater than 0.8 (indicating inclusion of exon 9 seen in ≥80% of transcripts, n = 323) had significantly higher survival than subjects where ≥80% of transcripts skipped exon 9 (n = 22, log-rank value = 0.00472).