Cyclization reactions of IMM-125 and oxidation of cyclosporin A amino-acid 1 in the α position of the double bond lead to the loss of in vitro immunosuppressive activity - Dieden, R.; Latinne, D.; Baldari, C.; Maton, N.; Aubry, A.; Verbeeck, R. K.; Zurini, M.; Lhoëst, G. J. J. (Spectroscopy, 2000)