Spectrophotometric Studies on the Thermodynamics of the ds-DNA Interaction with Irinotecan for a Better Understanding of Anticancer Drug-DNA Interactions
Figure 1
Absorption spectra of CPT-11 in the presence of ds-DNA at different concentrations. = 0.0, 6.1, 12.2, 17.9, 23.8, 29.5, 35.2, 40.8, 46.3, 51.8, 57.2, 62.5, 67.8, 73.0, and 78.1 μmol·L−1 for curves 1–15, and = 30.0 μmol L−1 in phosphate buffer (0.002 mol L−1, pH 7.5).
