Spectrophotometric Studies on the Thermodynamics of the ds-DNA Interaction with Irinotecan for a Better Understanding of Anticancer Drug-DNA Interactions

Figure 2

Typical plots of 𝐴₀/(𝐴−𝐴₀) versus 1/[ds-DNA] for the determination of the equilibrium binding constant (𝐾_𝑏) based on (1) of the ds-DNA binding of CPT-11 at various temperatures.