GC-MS and Cellular Toxicity Studies on Smokeless-Tobacco Show Alerting Cytotoxic effect on Human Gingiva and Lung Fibroblasts

Table 4

Selectivity of the eleven SLT extracts and doxorubicin against HT29 and HepG2 cancer cells compared with hGF and MRC5 normal cells.

Sample	hGF		MRC5		Average SI
	HT29	HepG2	HT29	HepG2
S1	0.67	1.14	0.05	0.09	0.48
S2	0.34	0.38	0.59	0.67	0.49
S3	0.64	0.34	0.14	0.07	0.29
S4	0.00	0.00	0.02	0.01	0.00
S5	0.38	0.37	0.05	0.05	0.21
S6	0.09	0.02	0.03	0.00	0.03
S7	0.17	0.15	0.29	0.27	0.22
S8	0.49	0.09	0.73	0.14	0.36
S9	0.03	0.02	0.86	0.76	0.41
S10	0.00	0.00	0.01	0.01	0.00
S11	0.17	0.13	0.26	0.21	0.19
Doxorubicin	3.84	3.59	3.11	2.91	3.36

<1, nonselective effect against the normal cell.