GC-MS and Cellular Toxicity Studies on Smokeless-Tobacco Show Alerting Cytotoxic effect on Human Gingiva and Lung Fibroblasts

Table 5

Major compounds present in SLT samples, structure, and cytotoxic effects against normal cells.

Compound		Structure	Effect	Reference
Nicotine derivatives	(1′s,2′s)-Nicotine-N′-oxide		Carcinogenic, promote tumor formation	[22, 23]
	Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-		Carcinogenic, cytotoxic against normal fibroblasts (MRC5)	[8]
	Pyridine, 3-(1-methyl-1H-pyrrol-2-yl)-
	Cotinine		Carcinogenic, genotoxicity, impaired osteogenesis	[24, 25]
Hentriacontane			Genotoxicity, impaired osteogenesis	[26, 27]
Hexadecanoic acid, methyl ester			Gingival recession, carcinogenic	[4]
Hexadecanoic acid, ethyl ester
1,2-Benzenedicarboxylic acid, diisooctyl ester			Fatal toxicity, carcinogenic	[3, 8]
Octadecanoic acid, methyl ester			Carcinogenic	[23]