Considerations in Raman Spectroscopy for Real-Time API Concentration Measurement at Tablet Press Feed Frame

Figure 6

(a) Surface plot after SNV correction and (b) Raman spectra of stationary powder versus flowing powder at the feed frame; (c–e) Raman spectra of stationary and flowing powder inside the feed frame of tablet press with (c) 8% APAP in lactose, (d) 10% APAP in lactose, and (e) 12% APAP in lactose. Solid lines are Raman spectra of flowing powder and dotted lines are Raman spectra of stationary powder inside the feed frame.

(a)

(b)

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(e)