Considerations in Raman Spectroscopy for Real-Time API Concentration Measurement at Tablet Press Feed Frame

Table 3

Comparison of PLS models.

Model comparison
Model performance parameters	APAP in lactose (flowing powder)	APAP in lactose (stationary powder)	APAP in MCC (stationary powder)
R2 training	0.9931	0.9997	0.9996
R2 cross-validation	0.9886	0.9793	0.9667
RMSEC	0.187	0.329	0.0482
RMSECV	0.351	0.448	0.59
RMSEP (%w/w)	0.286	0.39	0.572