Effects of Cytochrome P450 Inhibitors on Itraconazole and Fluconazole Induced Cytotoxicity in Hepatocytes

Figure 3

Effects of Cytochrome P450 inhibitors on the viability of hepatocytes treated with fluconazole or itraconazole. Values are mean  ± sd of 3 separate experiments. *Significant different (𝑃<.05) when compared to controls and drug only groups. Drug  = itraconazole or fluconazole; Cur  = curcumin; SKF  = SKF 525A.

(a) 0.1 mM Fluconazole

(b) 0.1 mM Itraconazole

(c) 1.0 mM Fluconazole

(d) 1.0 mM Itraconazole