Protective Effect of Liposome-Encapsulated Glutathione in a Human Epidermal Model Exposed to a Mustard Gas Analog
Figure 6
Protective effect of GSH-liposomes in the EpiDerm model. EpiDerm tissues were topically exposed to vehicle (1% DMSO) or 2.5 mM CEES in the absence or presence of GSH-liposomes or Blank liposomes (B-liposomes). After the MTS assay EpiDerm tissues were frozen, dissected, and photographed under a light microscope with 400x magnification (see Section 2). Violet color reflects the accumulation of the MTS formazan product in the proliferating keratinocytes. Note the disruption of the keratin filament structure in the stratum corneum in the presence of CEES, and the increase of proliferating (violet) basal keratinocytes in the presence of GSH-liposomes.
