Cytotoxicity and Genotoxicity of Panel of Single- and Multiwalled Carbon Nanotubes: In Vitro Effects on Normal Syrian Hamster Embryo and Immortalized V79 Hamster Lung Cells

Figure 4

DNA damage in cells after 24-hour treatment with MWCNTs, expressed as tail DNA (%) ± SEM. For each CNT, the small histogram represents the results obtained with negative (medium) and positive (0.125 mM MMS) control, both with (filled histogram) and without (open histogram) the Fpg enzyme. The large histogram represents data obtained for different concentrations of CNT. Sample concentrations are expressed as μg per cm² of cell culture surface. Three independent experiments were realized for each point. : statistically significant () compared to control; : statistically significant () compared to Fpg control. Data obtained for the negative control are shown on both histograms (note the different scales); the significance mark was omitted from the small histogram for better reading of the graph. (a), (c), (e), and (g) DNA breaks in V79 cells. (b), (d), (f), and (h) DNA breaks in SHE cells.

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