Effect of Metformin and Sitagliptin on Doxorubicin-Induced Cardiotoxicity in Rats: Impact of Oxidative Stress, Inflammation, and Apoptosis

Figure 2

Photomicrography of COX-2 immunostaining in the studied different animal groups. (a), (b), and (c) represent minimal expression sections from the control, metformin, and sitagliptin groups, respectively. (d) represents high COX-2 expression found in the DOX group. (e) and (f) represent significantly lower COX-2 expression found in the metformin/DOX and sitagliptin/DOX groups, respectively, as compared to (d). DAB was used as a chromogen and haematoxylin as nuclear and counter stain. Magnification used is 200x.

(a)

(b)

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(d)

(e)

(f)