Chalcone Scaffold in Anticancer Armamentarium: A Molecular Insight

Figure 9

Chalcones against multiple cancer cell lines. ((24a) to (24c)) GI₅₀ of 0.21 to 57.6 μM: topoisomerase-I and topoisomerase-II inhibition. (25) IC₅₀ of 0.15 to 0.52 μM: arrest cells in the G₂/M phase of the cell cycle and inhibit the polymerization of tubulin. Binds into the colchicine binding site of tubulin (molecular docking study). (26) IC₅₀ values of 0.22 to 1.80 μM: induced cell cycle arrest in G₂/M phase and inhibited the polymerization of tubulin; binds at the colchicine binding site of tubulin (from molecular docking analysis). (27) IC₅₀ value of 0.89 μmol/L: cell division cycle 25 (CDC25) inhibitor. (28) IC₅₀ values of 1.76 μmol/L: cell division cycle 25 (CDC25) inhibitor. (29) IC₅₀ value of 0.01 μg/mL and 0.04 μg/mL: molecular mechanism not studied. (30) IC₅₀ values of 6.4 μM and 8.5 μM: cytotoxic, molecular mechanism not studied. (31a) IC₅₀ value of 1.02 μM and 0.79 μM and (31b) IC₅₀ value of 0.81 μM and 1 μM: cytotoxic.