A Toxicological Evaluation of a Standardized Hydrogenated Extract of Curcumin (CuroWhite™)
Table 10
Summary of organ weights relative to body weight in male animals.
Group
Treatment and dose (mg/kg)
Fasting bw
Adrenals
Spleen
Thymus
Testes
Brain
Heart
Epididymis
Kidneys
Liver
Main groups
G1
Vehicle control
321.52 ± 47.57
0.02 ± 0.00
0.33 ± 0.07
0.10 ± 0.02
0.96 ± 0.11
0.57 ± 0.06
0.31 ± 0.02
0.40 ± 0.07
0.61 ± 0.04
2.65 ± 0.36
G2
Low dose-200
308.01 ± 24.27
0.02 ± 0.00
0.32 ± 0.06
0.09 ± 0.02
1.02 ± 0.08
0.59 ± 0.05
0.31 ± 0.03
0.42 ± 0.04
0.67 ± 0.05
2.98 ± 0.35
G3
Middle dose-400
310.90 ± 50.98
0.02 ± 0.00
0.33 ± 0.10
0.11 ± 0.04
0.98 ± 0.11
0.61 ± 0.08
0.34 ± 0.03
0.41 ± 0.07
0.67 ± 0.12
3.00 ± 0.46
G4
High dose-800
302.74 ± 28.47
0.02 ± 0.00
0.39 ± 0.14
0.10 ± 0.03
1.08 ± 0.12
0.57 ± 0.06
0.33 ± 0.02
0.42 ± 0.04
0.71 ± 0.07
3.54 ± 0.55
Recovery groups
G1R
Vehicle control-recovery
334.42 ± 47.40
0.04 ± 0.05
0.30 ± 0.02
0.10 ± 0.01
1.00 ± 0.08
0.55 ± 0.11
0.35 ± 0.02
0.43 ± 0.04
0.61 ± 0.04
2.49 ± 0.15
G4R
High-dose recovery-800
325.18 ± 47.55
0.02 ± 0.00
0.28 ± 0.06
0.07 ± 0.02
0.97 ± 0.11
0.55 ± 0.06
0.32 ± 0.03
0.41 ± 0.03
0.59 ± 0.02
2.65 ± 0.37
Symbols. ;; in the G4 male group. Notes. All values are expressed as mean ± SD. Statistical analysis of main groups using one-way ANOVA followed by Dunnett’s posttest as compared to vehicle-control. Statistical analysis of recovery groups using Student’s -test as compared to vehicle-control.
