In Vivo and In Vitro Toxicity Evaluation of Hydroethanolic Extract of Kalanchoe brasiliensis (Crassulaceae) Leaves
Table 2
Results of the biochemical dosages in the evaluation of subchronic toxicity of K. brasiliensis.
Parameters/groups
Control
250 mg/kg
500 mg/kg
1000 mg/kg
Males
Glucose (mg/dl)
56,375 ± 34,912
99,60 ± 23,787
93,00 ± 34,169
82,40 ± 22,534
Triglycerides (mg/dl)
109,80 ± 48,634
92,60 ± 22,974
92,20 ± 26,243
85,800 ± 38,311
Cholesterol (mg/dl)
70,10 ± 25,632
64,40 ± 22,244
82,20 ± 35,160
80,600 ± 16,273
TP (mg/dl)
4,556 ± 1,014
4,20 ± 0,8367
4,60 ± 0,5477
4,60 ± 1,140
AST (U/L)
120,30 ± 40,415
122,60 ± 26,81
214,20 ± 106,00
216,80 ± 113,7
ALT (U/L)
52,00 ± 26,051
37,40 ± 5,459
85,20 ± 40,69
85,60 ± 69,20
Urea (mg/dl)
51,80 ± 9,426
45,20 ± 11,713
42,20 ± 1,789
62,40 ± 8,877
Creatinine (mg/dl)
0,508 ± 0,0702
0,548 ± 0,08402
0,600 ± 0,0
0,694 ± 0,1915
Females
Glucose (mg/dl)
64,375 ± 30,863
97,80 ± 27,087
96,20 ± 37,265
123,80 ± 20,41
Triglycerides (mg/dl)
75,875 ± 22,10
152,20 ± 20,19
151,25 ± 98,215
94,00 ± 66,142
Cholesterol (mg/dl)
67,00 ± 37,74
80,40 ± 47,479
53,750 ± 17,84
64,40 ± 23,522
TP (mg/dl)
3,50 ± 0,9718
5,00 ± 0,7071
4,60 ± 0,8944
4,60 ± 0,1342
AST (U/L)
159,67 ± 84,714
130,60 ± 58,188
116,00 ± 6,519
156,00 ± 99,82
ALT (U/L)
65,11 ± 58,91
39,60 ± 5,030
45,00 ± 5,244
69,20 ± 31,83
Urea (mg/dl)
48,30 ± 9,31
47,00 ± 6,745
43,80 ± 6,907
49,20 ± 12,637
Creatinine (mg/dl)
0,7355 ± 0,4784
0,5975 ± 0,0689
0,925 ± 0,0957
0,600 ± 0,00
Values are expressed as mean ± standard deviation (). AST: aspartate aminotransferase; ALT: alanine aminotransferase; TP: total protein. presenting statistical difference with the control group ().
