An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin

Table 12

Summary of urinalysis parameters.

Parameters	Group; mg/kg bw/day
	Vehicle; 0	250	500	1000	Ref Item; 1000
	Males
Colour
Light Yellow	20/20	16/20	12/20	19/20	20/20
Yellow	-	4/20	1/20	1/20	-
Other	-	-	7/20	-	-
Appearance
Clear	20/20	20/20	20/20	20/20	20/20
Glucose
Negative	20/20	20/20	19/20	20/20	20/20
100	-	-	1/20	-	-
Protein
Negative	18/20	4/20	2/20	18/20	20/20
10	2/20	-	3/20	1/20	-
30	-	1/20	6/20	1/20	-
100	-	9/20	7/20	-	-
300	-	3/20	1/20	-	-
1000	-	3/20	1/20	-	-
Ketones Bodies
Negative	15/20	19/20	15/20	16/20	13/20
5	2/20	1/20	1/20	2/20	5/20
10	3/20	-	4/20	2/20	2/20
Bilirubin
Negative	20/20	19/20	18/20	20/20	20/20
0.5	-	1/20	1/20	-	-
3.0	-	-	1/20	-	-
Urobilinogen
Normal	20/20	20/20	17/20	20/20	20/20
1.0	-	-	2/20	-	-
12.0	-	-	1/20	-	-
Nitrite
Negative	7/20	2/20	11/20	12/20	10/20
Positive	13/20	18/20	9/20	8/20	10/20
Specific Gravity
1.005	4/20	8/20	4/20	3/20	4/20
1.010	10/20	10/20	14/20	14/20	13/20
1.015	6/20	2/20	2/20	3/20	3/20
pH
6.5	1/20	-	-	-	-
7.0	2/20	-	1/20	-	3/20
7.5	5/20	8/20	3/20	10/20	7/20
8.0	6/20	6/20	11/20	4/20	5/20
8.5	1/20	4/20	3/20	3/20	4/20
9.0	5/20	2/20	2/20	3/20	1/20
Occult Blood
Negative	20/20	20/20	17/20	19/20	19/20
5	-	-	3/20	-	1/20
10	-	-	-	1/20	-
Leucocytes
Negative	20/20	20/20	20/20	19/20	20/20
10	-	-	-	1/20	-
Microscopy
Epithelial Cell
0	3/20	3/20	3/20	3/20	1/20
1+	14/20	12/20	8/20	13/20	14/20
2+	3/20	5/20	8/20	3/20	3/20
3+	-	-	1/20	1/20	2/20
Casts/Crystals
1+	6/20	4/20	6/20	7/20	11/20
2+	1/20	12/20	7/20	4/20	4/20
3+	4/20	4/20	7/20	2/20	1/20
4+	9/20	-	-	7/20	4/20
Abnormal Cells
NIL	20/20	20/20	20/20	20/20	20/20
	Females
Colour
Light Yellow	20/20	20/20	20/20	18/20	20/20
Yellow	-	-	-	2/20	-
Appearance
Clear	20/20	20/20	20/20	20/20	20/20
Glucose
Negative	20/20	20/20	20/20	20/20	20/20
Protein
Negative	14/20	12/20	19/20	12/20	16/20
10	2/20	3/20	1/20	5/20	2/20
30	-	1/20	-	1/20	2/20
100	2/20	4/20	-	2/20	-
1000	2/20	-	-	-	-
Ketones Bodies
Negative	20/20	20/20	20/20	20/20	20/20
Bilirubin
Negative	20/20	20/20	20/20	20/20	20/20
Urobilinogen
Normal	20/20	20/20	20/20	20/20	20/20
Nitrite
Negative	4/20	5/20	5/20	6/20	18/20
Positive	16/20	15/20	15/20	14/20	2/20
Specific Gravity
1.005	3/20	2/20	2/20	4/20	3/20
1.010	8/20	16/20	11/20	11/20	15/20
1.015	9/20	2/20	7/20	5/20	2/20
pH
5.5	1/20	-	-	-	-
6.0	1/20	-	-	-	-
6.5	3/20	-	-	1/20	-
7.0	2/20	1/20	3/20	2/20	-
7.5	2/20	4/20	3/20	3/20	5/20
8.0	3/20	9/20	7/20	6/20	7/20
8.5	3/20	4/20	2/20	5/20	7/20
9.0	5/20	2/20	5/20	3/20	1/20
Occult Blood
Negative	19/20	18/20	20/20	14/20	17/20
5	1/20	-	-	2/20	2/20
10	-	-	-	2/20	-
50	-	1/20	-	2/20	1/20
250	-	1/20	-	-	-
Leucocytes
Negative	17/20	20/20	20/20	20/20	20/20
Microscopy
Epithelial Cell
0	1/20	-	-	4/20	2/20
1+	12/20	14/20	14/20	7/20	9/20
2+	7/20	6/20	6/20	8/20	6/20
3+	-	-	-	1/20	3/20
Casts/Crystals
1+	5/20	5/20	4/20	5/20	3/20
2+	9/20	11/20	12/20	12/20	9/20
3+	6/20	4/20	4/20	3/20	8/20
Abnormal Cells
NIL	20/20	20/20	20/20	20/20	20/20